Intermediates in the synthesis of 17.beta.-acyl-3-carboxy-andros

Details Intermediates in the synthesis of 17.beta.-acyl-3-carboxy-andros Intermediates in the synthesis of 17.beta.-acyl-3-carboxy-andros

1990-12-18

1991-12-24

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21168

Patent

active

050754505

ABSTRACT:
New intermediates in the synthesis of 17.beta.-acyl-3-carboxy-androsta-3,5-dienes, of the formula: ##STR1## wherein R.sup.2 is 2-thiopyridyl, and

REFERENCES:
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patent: 4859681 (1989-08-01), Rasmusson et al.
patent: 4882319 (1989-11-01), Holt et al.
patent: 4910226 (1990-03-01), Holt et al.
J. Med. Chem., Rasmusson et al., Azasteroids as Inhibitors of Rat Prostatic 5.alpha.-Reductase, 1984, 27, (12), pp. 1690-1701.
J. Pharm. Sci., Doorenbos et al., 4,17.alpha.-Dimethyl-4-aza-5.alpha.-androstan-17.beta.-ol Acetate and Related Azasteroids, 1971, 60, 8, pp. 1234-1235.
Steroids, vol. 35, No. 1 (Jan. 1980), Murphy et al. pp. 1-7.
J. Med. Chem. 33, 943-950, Inhibition of Steroid 5.alpha.-Reductase by Unsaturated 3-Carboxysteroids, Holt et al.

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