Intermediates in the preparation of substituted alkenoic acids

Details Intermediates in the preparation of substituted alkenoic acids Intermediates in the preparation of substituted alkenoic acids

1998-09-10

1999-11-23

Fan, Jane

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

546209, 546 14, 548237, C07D41312

Patent

active

059903082

ABSTRACT:
This invention relates to a highly selective process for preparation of E-.omega.-phenyl-.omega.-(3-pyridyl)-.omega.-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as to intermediates therefore.

REFERENCES:
patent: 4980478 (1990-12-01), Hatanaka et al.
patent: 5100889 (1992-03-01), Misra et al.
patent: 5153327 (1992-10-01), Misra et al.
patent: 5158967 (1992-10-01), Hall
Soyka, R., et al., J. Med. Chem., 37, 26-39, (1994).
Takeuchi, K., et al., Bioorg. & Med. Chem. Letters, 2, 743-755, (1994).
Gilchrist, T., and Summersell, R., Tetrahedron Letters, 28, 1469-1472, (1987).
Parrain, J., et al., Tetrahedron Letters, 31, 1857-1860, (1990).
Zhang, H., et al., J. Org. Chem., 55, 1857-1867, (1990).
Takeuchi, K., et al., J. Org. Chem., 60, 156-168, (1995).
Roth, G., and Farina, V., Tetrahedron Letters, 36, 2191-2194, (1995).
Farina, V., et al., J. Org. Chem., 59, 5905-5911, (1994).
Farina, V., and Krishnan, B., J. Am. Chem. Soc., 113, 9585-9595, (1991).
Stracker, E., and Sweifel, G., Tetrahedron Letters, 32, 3329-3332, (1991).
Deshpande, M., Tetrahedron Letters, 35, 5613-5614, (1994).
Malm, J., et al., Tetrahedron Letters, 33, 2199-2202, (1992).
Yang, Y., and Martin, A., Synthetic Communications, 22, 1757-1762, (1992).
Yamamoto, Y., and Yanagi, Akihiko, Heterocycles, 16, 1161-1164, (1981).
Palmisano, G., and Santagostino, M., Helvetica Chimica Acta, 76, 2356-2366, 1993.
Mitchell, T., Synthesis, 803-815, (1992).
Ishikura, M., et al., Heterocycles, 22(11), 2475-2478 (1984).
Negishi, E., et al., Heterocycles, 18, 117-122 (1982).
Sakamoto, T., et al., Heterocycles, 31(2), 219-221, (1990).

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