Intermediates in the preparation of ranitidine

Details Intermediates in the preparation of ranitidine Intermediates in the preparation of ranitidine

1982-06-04

1983-11-01

Raymond, Richard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30752, C07D30754

Patent

active

044131356

ABSTRACT:
The invention relates to a process for the preparation of ranitidine of formula (I) ##STR1## which comprises reacting a thiol of formula (II) ##STR2## with an alkylating agent of formula (III) ##STR3## where L is a leaving group, preferably halogen. The invention also relates to novel intermediates, the thiol of formula (II) ##STR4## in the form of a stable acid addition salt, and the isothiourea of formula (IV) ##STR5## and stable acid additions salts thereof.

REFERENCES:
patent: 4255440 (1981-03-01), Price et al.

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