Intermediates in the preparation of alpha1(((1,1-dimethylethyl)

Details Intermediates in the preparation of alpha1(((1,1-dimethylethyl) Intermediates in the preparation of alpha1(((1,1-dimethylethyl)

1989-11-03

1990-08-28

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564344, 564356, 564357, 564358, 564365, 568337, C07C25124

Patent

active

049527290

ABSTRACT:
There is disclosed an improved process for preparing albuterol which comprises reacting a 5-(haloacetyl)-2-hydroxybenzaldehyde with 1,1-dimethylethanamine in an organic solvent and in an inert atmosphere to form 5-[[(1,1-dimethylethyl)amino]acetyl]-2-hydroxybenzaldehyde and reducing the carbonyl functions to the corresponding hydroxy groups to form albuterol.

REFERENCES:
patent: 3644353 (1972-02-01), Lunts et al.
patent: 4011258 (1977-03-01), Wetterlin et al.
patent: 4021485 (1977-05-01), Schromm et al.
patent: 4154761 (1979-05-01), Collins et al.
Hansske et al., Tetrahedron, vol. 40, No. 1, pp. 125-135, (1984).
Brodbeck et al., J. Org. Chem. vol. 35, No. 10, pp. 3552-3558.
Collin, Journal of Medicinal Chemistry, 13, No. 4, 674 (1970).
Hudlicky, Reductions in Organic Chemistry, pp. 99-101, 109-113, Halsted Press.
Morrison et al., Organic Chemistry, 3 ed., Allyn and Bacon, Inc., Boston (1973), pp. 630, 636, 637.

Affiliated with

Also associated with

Rating

Intermediates in the preparation of alpha1(((1,1-dimethylethyl) does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intermediates in the preparation of alpha1(((1,1-dimethylethyl) , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediates in the preparation of alpha1(((1,1-dimethylethyl) will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1591123