Intermediates for use in the preparation of cephalosporin antibi

Details Intermediates for use in the preparation of cephalosporin antibi Intermediates for use in the preparation of cephalosporin antibi

1981-03-03

1983-02-22

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, C07D50118, A61K 31545

Patent

active

043749836

ABSTRACT:
(6R,7R)-7-amino-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylic acid monoperchlorate is a useful intermediate in the preparation of (6R,7R)-7-amino-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylate dihydrochloride by enzymatic deacylation of 7-amino-3-(1-pyridiniummethyl) cephalosporin compounds and may be isolated in a substantially pure crystalline form. The said dihydrochloride and its solvates may be used as intermediates in the preparation of a wide range cephalosporin compounds.

REFERENCES:
patent: 3207755 (1965-09-01), Abraham et al.
patent: 3280118 (1966-10-01), Eardley et al.
patent: 3422099 (1969-01-01), Crast

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