Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Patent
1981-03-03
1983-01-18
Rizzo, Nicholas S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
424246, 544 25, C07D50118
Patent
active
043693130
ABSTRACT:
(6R,7R)-7-amino-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylate dihydrochloride and its solvates are prepared in substantially pure form and can be acylated by conventional methods to yield a wide variety of cephalosporin antibiotics. The dihydrochloride is advantageously prepared in the form of its crystalline dihydrate. Processes for the preparation of the dihydrochloride and its solvates are described.
The dihydrochloride and its solvates are particularly useful in the preparation of (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(2-carboxyprop-2-oxyimino)acetami do]-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylate, in the course of the preparation of which the novel N,N-dimethylformamide solvate of (6R,7R)-7-[(Z)-2-(2-tritylaminothiazol-4-yl)-2-(2-t-butoxyprop-2-oxyimino) acetamido[-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylate may be isolated in substantially pure crystalline form.
REFERENCES:
patent: 3207755 (1965-09-01), Abraham et al.
patent: 3234224 (1966-02-01), Schenicer et al.
patent: 3280118 (1966-10-01), Eardley et al.
patent: 3422099 (1969-01-01), Crast
Gane Timothy L.
Jones William R.
Trivedi Harish S.
Glaxo Group Limited
Rizzo Nicholas S.
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