Intermediates for tricyclic benzodiazepines

Details Intermediates for tricyclic benzodiazepines Intermediates for tricyclic benzodiazepines

1975-03-11

1976-06-22

Garner, Vivian

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602393T, 260295AM, 260295R, 260463, 260471A, 260562B, 260570AB, C07C 9710, C07C10342

Patent

active

039651517

ABSTRACT:
Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.

REFERENCES:
chem. Abstracts, 69: 96796n.
Chem. Abstracts, 75: 76852y.

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