Intermediates for the synthesis of polypropionate antibiotics

Details Intermediates for the synthesis of polypropionate antibiotics Intermediates for the synthesis of polypropionate antibiotics

2007-04-06

2008-03-04

Elyer, Yvonne (Bonnie) (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

C568S008000, C568S300000, C568S579000, C568S700000, C546S006000, C546S257000, C548S400000, C548S407000, C548S413000, C549S005000

Reexamination Certificate

active

07339066

ABSTRACT:
The invention relates to intermediate compounds of the formulawherein R1is H or a protecting group, R2and R3each independently represent H, methyl, or a leaving group, provided that at least one, but not both, of R2and R3is a leaving group. The intermediate compounds are useful for the synthesis of discodermolide, its derivatives, and related compounds.

REFERENCES:
patent: WO2002057251 (2002-07-01), None
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Parker, et al., “A Strategy for Exploiting the Pseudosymmetry of the C1-C13 Stretch of Discodermolide,” Organic Letters 2004, 6(9):1413-1416.
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Tsai, et al., Application of [2,3] Sigmatripic (wittig) . . . ] J. AmChem Soc 1985, 107:3915-3918.
Hung et al., Synthesis of Discodermolides Useful for Investigating Microtubule Binding and Stabilization, Journal of the American Chemical Society (1996), 118(45), 11054-11080.

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