Intermediates for the synthesis of irbesartan

Details Intermediates for the synthesis of irbesartan Intermediates for the synthesis of irbesartan

2007-11-27

2007-11-27

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

11348944

ABSTRACT:
Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4′-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.

REFERENCES:
patent: 5270317 (1993-12-01), Bernhart et al.
patent: 5310929 (1994-05-01), Ardecky et al.
patent: 5541209 (1996-07-01), Spinale et al.
patent: 5559233 (1996-09-01), Bernhart et al.
patent: 5629331 (1997-05-01), Caron et al.
patent: 0 508 393 (1992-10-01), None
patent: 0 782 996 (1997-07-01), None
patent: 2 780 403 (1999-12-01), None
patent: 2 281 072 (1995-02-01), None
patent: WO 94/11012 (1994-05-01), None
patent: WO 2004/007482 (2004-01-01), None
Caplus English Abstract DN 145:293070 , WO 2006089927 , Huguet Clotet et al , Aug. 31, 2006.
Caplus English Abstract DN 147:31119, IN 2003MA00471 , Reddy Reguri et al. Mar. 4, 2005.
Caplus English Abstract DN 144:22926, Abstract WO 2005113518, Dec. 1, 2005.
N. Miyaura et al., “A New Stereospecific Cross-Coupling by the Palladium-Catalyzed Reaction of 1-Alkenylboranes with 1-Alkenyl or 1-Alkynyl Halides,” Tetrahedron Letters, No. 36, 1979, p. 3437-3440.
N. Miyaura, A. Suzuki, “Stereoselective Synthesis of Arylated (E)-Alkenes by the Reaction of Alk-1-enylboranes with Aryl Halides in the Presence of Palladium Catalyst”, J.C.S. Chem Commun. 1979, pp. 866-867.
Murugesan, Natesan, et al., “Discovery Of N-Isoxazolyl Biphenylsulfonamides As Potent Dual Angiotensin II And Endothelin A Receptor Antagonists”,J. of Med. Chem. (2002), 45(18), 3829-3835.
Bernhart C.A., et al., “A New Series of Imidazolones: Highly Specific and Potent Nonpeptide AT1Antiotensin II Receptor Antagonists”,J. of Med. Chem. vol. 36, No. 22, 1993, pp. 3371-3380.

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