Intermediates for the synthesis of bisindolylmaleimides

Details Intermediates for the synthesis of bisindolylmaleimides Intermediates for the synthesis of bisindolylmaleimides

1995-05-25

1997-03-25

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

552105, 548478, 556444, 558 46, 558 47, 560111, 560160, 560266, 564 92, 564 93, 564 98, 564 99, 564183, 564224, 564402, 564508, 564568, 564660, C07C 43303, C07C31708

Patent

active

056146477

ABSTRACT:
The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.

REFERENCES:
patent: 4923986 (1990-05-01), Murakata et al.
patent: 5057614 (1991-10-01), Davis et al.
patent: 5438050 (1995-08-01), Kleinschroth et al.
Derwent Abstract 90-132947/18; 21.10.88-DE-835842 (1988).
Derwent Abstract 92-274042/33;90.11.20 90JP-314628 (1990).
Meier, et al., Tetrahedron Letters, 34:33, 5277-5280 (1993).
Wilkinson, et al., Bichem. J., 294, 335-337 (1993).
Bit, et al., J. Med. Chem., 36, 21-29 (1993).
Martiny-Baron, et al., The Journal of Biological Chemistry, 268:13, 9194-9197 (1993).
Krakowiak, et al, Synlett, 611-620, (Sep. 1993).
Mulqueen, et al., Agents Actions, 37, 85-89 (1992).
Davis, et al., J. Med. Chem., 35, 177-184 (1992).
Davis, et al., J. Med. Chem., 35, 994-1001 (1992).
Toullec, et al., The Journal of Biological Chemistry, 266:24, 15771-15781 (1991).
Nixon, et al., Drugs Exptl. Clin. Res., 17:8, 389-393 (1991).
Davis, et al., Tetrahedron Letters, 31:36, 5201-5204 (1990).
Brenner, et al., Tetrahedron Letters, 44:10, 2887-2892 (1988).
Joyce, et al., The Journal of Organic Chemistry, 52:7, 1177-1186 (1987).
Buchdunger, et al., Proc. Natl. Acad. Sci. USA, 91, 2334-2338 (Mar. 1994).
Kobayashi, et al., The American Physiological Society, H1214-H1220 (1994).
Felsenstein, et al., Neuroscience Letters, 174 173-176 (1994).
Demaerschalck, et al., Biochimica et Biophysica Acta, 1181 214-218 (1993).
Shimohama, et al., Neurology, 43 1407-1413 (1993).
Ansell, et al., Journal of Chemical Society, 1788-1795 (1957).
Rudloff, et al., Canadian Journal of Chemistry, 35 315-321 (1957).
Tius, et al., J. Am. Chem. Soc., 108 1035-1039 (1986).
Gillet, et al., Synthesis, 355-360, (May 1986).
DeCamp Schuda, et al., Synthesis, 309-312, (Apr. 1986).
Kaneko, et al., Tetrahedron Letters, 26, 4015-4017 (1985).
Edge, et al., Chemistry & Industry, 18:130, (Feb. 1991).
Steglich, et al., Angew: Chem. Int. Ed. Engl., 19: (6): 459-460 (1980).
Harris, et al., Tetrahedron Letters, 34 (51): 8361-8364 (1993).
Bergman, et al., Tetrahedron Letters, 28: (38): 4441-4444 (1987).
Behling, et al., Tetrahedron Letters, 30: (1): 27-30 (1989).
Alexakis, et al., Tetrahedron Letters, 45: (19): 6197-6202 (1989).
Lipshutz, et al., Tetrahedron Letters, 29: (8): 893-896 (1988).
Fieser and Fieser, Reagents for Organic Synthesis, XII, John Wiley & Sons, p. 108 (1986).
Rudloff, et al., "Hydrogenolysis of Carbohydrates", Canadian Journal of Chemistry, vol. 35, 315-321 (1957).
Rosenthal, et al., "The reaction of unsaturated carbohydrates with carbon monoxide and hydrogen. III. Structure and stereochemistry of the hexitols from 3,4-DI-O-Acetyl-D-Arabinal", Canadian Journal of Chemistry, vol. 42, 2025-2027 (1964).

Affiliated with

Also associated with

Rating

Intermediates for the synthesis of bisindolylmaleimides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intermediates for the synthesis of bisindolylmaleimides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediates for the synthesis of bisindolylmaleimides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2204677