Intermediates for the synthesis of anthrapyrazolone anticancer a

Details Intermediates for the synthesis of anthrapyrazolone anticancer a Intermediates for the synthesis of anthrapyrazolone anticancer a

1993-10-25

1995-02-28

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23154

Patent

active

053938860

ABSTRACT:
This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphen yl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.

REFERENCES:
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patent: 4608439 (1986-08-01), Johnson et al.
patent: 4672129 (1987-06-01), Beylin et al.
G. Zagotto et al., Bioorganic & Medicinal Chemistry, 2(7), 1992, p659.
H. D. Showalter et al., J. Med. Chem., 27, 1984, p255.
H. Showalter et al., J. Med. Chem., 30, 1987, p121.
W. R. Leopold, Cancer Research, 45, 1985, p5532.
V. G. Beylin et al., J. Heterocyclic Chem., 26, 1989, p85.

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