Intermediates for the synthesis of 4-demethoxydaunorubicin

Details Intermediates for the synthesis of 4-demethoxydaunorubicin Intermediates for the synthesis of 4-demethoxydaunorubicin

1978-06-05

1979-07-17

Curtis, Allen B.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C 4966, C07C 4973, C07C 6344

Patent

active

041614801

ABSTRACT:
The present invention encompasses novel intermediates having the following structural formulas: ##STR1## wherein X is hydrogen, methoxy, or hydroxy; ##STR2## wherein X is hydrogen, methoxy, or hydroxy; and ##STR3## wherein X is hydrogen, methoxy, or hydroxy. Compounds of the present invention are useful in synthesizing 4-demethoxydaunorubicin, daunorubicin, adriamycin, and carminomycin which are potent antitumor agents.

REFERENCES:
patent: 3803124 (1974-04-01), Arcamone et al.
patent: 4046878 (1977-09-01), Patelli et al.
Cancer Treatment Reports, vol. 60 (7), pp. 829-834, F. Arcamone et al. (1976).
Can. Jol. Bio. Chem., vol. 51, pp. 466-467, C. M. Wong et al. 1973.
Jol. Amer. Chem. Soc., vol. 98, pp. 1967-1969, A. S. Kende et al. 1976.
Jol. Amer. Chem. Soc., vol. 98, pp. 1967-1971, T. H. Smith et al. 1976.

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