Intermediates for the synthesis of 4-amino-4,5-dihydro-2-furanca

Details Intermediates for the synthesis of 4-amino-4,5-dihydro-2-furanca Intermediates for the synthesis of 4-amino-4,5-dihydro-2-furanca

1985-03-13

1986-05-13

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549480, 556420, 560160, 560157, 560171, C07D30724, C07D30730, C07F 718

Patent

active

045888256

ABSTRACT:
This application relates to a stereospecific process for preparing specific enantiomers of 4-amino-4,5-dihydro-2-furancarboxylic acid and C.sub.1-6 lower alkyl esters thereof. These compounds are .gamma.-aminobutyric acid transaminase inhibitors useful in the treatment of epilepsy.

REFERENCES:
patent: 3960927 (1976-06-01), Metcalf et al.
patent: 4524076 (1985-06-01), Metcalf et al.
Oppolzer et al, JACS, vol. 104 (1982) pp. 4978 & 4979.
Allan et al, Chemical Abstracts, vol. 101 (1984) 54821r.

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