Intermediates for the synthesis of 19-nor vitamin D compounds

Details Intermediates for the synthesis of 19-nor vitamin D compounds Intermediates for the synthesis of 19-nor vitamin D compounds

1991-05-28

1992-02-04

Mars, Howard T.

Organic compounds -- part of the class 532-570 series

Organic compounds

9,10-seco-cyclopentanohydrophenanthrene ring system or...

C07C 300

Patent

active

050861913

ABSTRACT:
New intermediate compounds that can be used effectively for the synthesis of a broad range of 1.alpha.-hydroxy-19-nor-vitamin D compounds. These novel intermediates are characterized by a group selected from hydroxy methyl (--CH.sub.2 OH), carboxaldehyde (--CHO), and carboxy ester (--COOAlkyl) at the carbon 22 position of the side chain of a 19-nor-vitamin D nucleus. Intermediates of this type are useful for the introduction of side chain units and thus represent important synthons for the preparation of many different 19-nor-vitamin D compounds.

REFERENCES:
Perlman, et al., Tetrahedron Letters, vol. 31 (13) pp. 1823-1824, 1990.

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