Intermediates for the synthesis of 16-phenoxy-prostatrienoic aci

Details Intermediates for the synthesis of 16-phenoxy-prostatrienoic aci Intermediates for the synthesis of 16-phenoxy-prostatrienoic aci

1994-09-30

1996-11-05

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

549214, 549415, 549473, 554119, 554140, 554148, 556440, C07C 69587

Patent

active

055719368

ABSTRACT:
Intermediate compounds represented as formula (I) useful for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof are disclosed. ##STR1## wherein R is tetrahydropyranyl, tetrahydrofuranyl, 2-ethoxyethyl, 3-t-butyldimethylsilyl triisopropylsilyl or triethylsilyl group; R.sup.1 and R.sup.2 are independently hydrogen or ester-forming group; P is hydrogen, trimethylsilyl or tri-n-butyltin; and wavy line means epistereoisomeric mixture.

REFERENCES:
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patent: 4178475 (1979-12-01), Van Horn et al.
patent: 4600785 (1986-07-01), Cooper et al.
Acta. Chemica Scandinavia B 36 (1982) 179-185.
J. Am. Chem. Soc. 1990, 112, 8042-8047.
J. Med. Chem. 1991, 24, 1353-1359.
J. Org. Chem. 1980, 45, 4740-4747.
Tetrahedron Letters No. 18, 1975, 1509-1512.
Tetrahedron Vo. 35, pp. 2931-2938, 1979.
Tetrahedron Letters No. 51, 1975, 4615-4618.

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