Intermediates for the stereochemical inversion of (2S,3S)-2-amin

Details Intermediates for the stereochemical inversion of (2S,3S)-2-amin Intermediates for the stereochemical inversion of (2S,3S)-2-amin

1992-12-18

1994-02-08

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 17, 560250, 564185, 564212, 564219, 564302, 564304, 548215, C07C38100, C07C32300, C07C32100

Patent

active

052849660

ABSTRACT:
Intermediates for transforming (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R)-enantiomers are described. The final compounds are useful intermediates for the synthesis of antibiotics like Chloramphenicol, Thiamphenicol and Florfenicol.

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C. Giordano et al., Tetrahedron Letters, "New Strategy for Racemization of 2-Amino-1,3-Propanediols, Key Intermediates for the Synthesis of Antibiotic Drugs", vol. 29, No. 43, pp. 5561-5564, 1988.
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