Intermediates for the production of podophyllotoxin and related

Details Intermediates for the production of podophyllotoxin and related Intermediates for the production of podophyllotoxin and related

1985-12-05

1988-03-29

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

556441, 549300, 549298, 549346, 562466, 560 51, 560 53, C07D31770, C07F 704

Patent

active

047345128

ABSTRACT:
There are disclosed intermediates which can be converted into podophyllotoxin and related compounds, which are known antineoplastic agents. There are also disclosed processes for the preparation of such intermediates, and processes for the conversion of the intermediates into known intermediates which are readily converted into podophyllotoxin and related compounds.

REFERENCES:
patent: 4294763 (1981-10-01), Kende et al.
patent: 4391982 (1983-07-01), Kende et al.
Wagh et al., Chem. Abstract, 84, 59019a (1976).
Hartwell et al., Fortschr. Chem. Organische Naturstoffe, 15, 83-87 (1958).
Wagh et al., Indian J. Chem., 13, 882 (1975).
Meyers et al., J. Org. Chem., 46, 3881 (1981).
Derwent No. 84-235114-Abstract of Japan Kokai, J-59-141575A (8/14/84).
Derwent No. 84-235113-Abstract of Japan Kokai, J 59-141574A (8/14/84).

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