Intermediates for the production of podophyllotoxin

Details Intermediates for the production of podophyllotoxin Intermediates for the production of podophyllotoxin

1987-12-07

1989-07-04

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562466, 562462, 560 56, 560 53, 558274, 558271, 558270, C07D31744, C07C 6976

Patent

active

048452483

ABSTRACT:
There are disclosed intermediate which can be converted into podophyllotoxin and related compounds, which are known antineoplastic agents. There are also disclosed processes for the preparation of such intermediates, and processes for the conversion of the intermediates into known intermediates which are readily converted into podophyllotoxin and related compounds.

REFERENCES:
patent: 4294763 (1981-10-01), Kende et al.
patent: 4391982 (1983-07-01), Kende et al.
patent: 4644072 (1987-02-01), Vyas et al.
Schreier, C. A., 60, 5408h (1964).
Wagh et al., Indian J. Chem., 13, 882 (1975).
Meyers et al., J. Org. Chem., 46, 3881 (1981).
Hartwell et al., Fortschr. Chem. Organische Naturstoffe, 15, 83-87 (1958).

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