Intermediates for the production of epipodophyllotoxin and relat

Details Intermediates for the production of epipodophyllotoxin and relat Intermediates for the production of epipodophyllotoxin and relat

1985-04-12

1987-02-17

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548240, 548242, 549298, 549299, 558416, 560 51, 560 53, 560 56, 560 42, 562462, 562467, 562451, C07D31744, C07C 6976

Patent

active

046440720

ABSTRACT:
There is provided a novel and efficient stereoselective total synthesis of epipodophyllotoxin and related epipodophyllotoxin compounds of the general formula ##STR1## wherein R.sup.1 and R.sup.2 each are independently hydrogen or (lower)alkoxy, or R.sup.1 and R.sup.2, taken together, is methylenedioxy; R.sup.4 and R.sup.6 each are independently hydrogen or (lower)alkoxy; and R.sup.5 is hydrogen or a phenol-protecting group; or an acid addition salt thereof. The present invention also provides novel intermediates and processes for the preparation of said intermediates, which are then converted into known antineoplastic agents.

REFERENCES:
patent: 3524844 (1970-08-01), Juxler et al.
patent: 3716574 (1973-02-01), Howard et al.
patent: 4294763 (1981-10-01), Kende et al.
patent: 4391982 (1983-07-01), Kende et al.
Gensler et al., J. Org. Chem., 31, 4004-4008 (1966).
Gensler et al., JACS, 82, 1714-1727 (1960).
Kende et al., J. Org. Chem., 46, 2826-2828 (1981).
Murphy et al., J.C.S. Perkin I, 271-276 (1982).
Rodrigo, J. Org. Chem., 45, 4538-4540 (1980).

Affiliated with

Also associated with

Rating

Intermediates for the production of epipodophyllotoxin and relat does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intermediates for the production of epipodophyllotoxin and relat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediates for the production of epipodophyllotoxin and relat will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1938729