Intermediates for the production of epipodophyllotoxin and relat

Details Intermediates for the production of epipodophyllotoxin and relat Intermediates for the production of epipodophyllotoxin and relat

1991-10-04

1992-06-09

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 53, 562462, C07D32710, C07C 6976, C07C 5986

Patent

active

051208628

ABSTRACT:
There is provided a novel and efficient stereoselective total synthesis of epipodophyllotoxin and related epipodophyllotoxin compounds of the and present invention ##STR1## wherein R.sup.1 and R.sup.2 each are independently hydrogen or (lower)alkoxy, or R.sup.1 ll and R.sup.2, taken together, is methylenedioxy; R.sup.4 and R.sup.6 each are independently hydrogen or (lower)alkoxy; and R.sup.5 is hydrogen or a phenol-protecting group; or an acid addition salt thereof. The present ivnention also provides novel intermediates and processes for the preparation of said intermediates, which are then converted into known antineoplastic agents.

REFERENCES:
CA94:139391n Trapping the intermediate . . . ketones. A convenient . . . .gamma.-hydroxy ketones. Murphy et al. p. 724, 1980.

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