Intermediates for the production of epipodophyllotoxin and relat

Details Intermediates for the production of epipodophyllotoxin and relat Intermediates for the production of epipodophyllotoxin and relat

1989-07-14

1991-04-30

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

558309, 558426, 549299, 549433, C07D49304, C07D30792, C07C25547

Patent

active

050119486

ABSTRACT:
There is provided a novel and efficient stereoselective total synthesis of epipodophyllotoxin and related epipodophyllotoxin compounds of the general formula ##STR1## wherein R.sup.1 and R.sup.2 each are independently hydrogen or (lower)alkoxy, or R.sup.1 and R.sup.2, taken together, is methylenedioxy; R.sup.4 and R.sup.6 each are independently hydrogen or (lower)alkoxy; and R.sup.5 is hydrogen or a phenol-protecting group; or an acid addition salt thereof. The present invention also provides novel intermediates and processes for the preparation of said intermediates, which are then converted into known antineoplastic agents.

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