Intermediates for the preparation of optically active cyclobutan

Details Intermediates for the preparation of optically active cyclobutan Intermediates for the preparation of optically active cyclobutan

1992-11-12

1993-10-26

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

552105, 560 39, 560 40, 560106, 560123, 560251, 564152, 564158, C07C23540, C07F 718

Patent

active

052568067

ABSTRACT:
Novel intermediates useful in the preparation of the optically active antiviral compound [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobut yl]-1,9-dihydro-6H-purin-6-one are described.

REFERENCES:
patent: 4855466 (1989-08-01), Zahler et al.
patent: 4918075 (1990-04-01), Zahler et al.
patent: 5126345 (1992-06-01), Slusarchyk et al.
W. Slusarchyk, et al. SQ33,054: A Potent Member of a New Class of Nucleosides-Analog Antivirals--Abstract No. 1330--XXIX Inter-science on Antimicrobial Agents & Chemo., Sep. 17-20, 1989, Houston, Tex.
Oral report by the Japanese Company Nippon Kayaku. Gordon Research Conf., Jul. 24-28, 1989, New Hampton, N.H.
W. Slusarchyk et al. Synthesis of SQ33,054, A Novel Cyclobutane Nucleoside With Potent Antiviral Activity; Tetrahedron Letters, vol. 30, p. 6453 (1989).
Ichikawa et al., "Enantio and Diastereo-selective Synthesis . . . ", J. Chem. Soc., Chem Commun, 1989, pp. 1919-1921.
Norbeck et al., "Cyclobut A and Cyclobut G . . . ", J. Med. Chem., vol. 33, pp. 1281-1285 (1990).
M. Honjo, et al., Synthesis of the Carbocyclic Analogue of Oxetanocin A.sup.1, Chem. Pharm. Bull. 37(5) 14-13-1415 (1989).
Y. Hayashi, et al.; Asymmetric [2+2 ] Cycloaddition Reaction Catalyzed by a Chiral Titanium Reagent. Chemistry Letters, pp. 793-796 (1989).

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