Intermediates for the preparation of octahydro-1H-benzo[4,5]furo

Details Intermediates for the preparation of octahydro-1H-benzo[4,5]furo Intermediates for the preparation of octahydro-1H-benzo[4,5]furo

1980-05-19

1981-04-07

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424258, C07D21704, A61K 3147

Patent

active

042607612

ABSTRACT:
Octahydro-1H-benzo[4,5]furo[3,2-e]isoquinoline compounds and processes for their manufacture are provided. The compounds correspond to the formula ##STR1## These compounds exhibit both analgesic and narcotic antagonistic properties, as well as low abuse liability.
Novel intermediate compounds are also provided which have the formula ##STR2##

REFERENCES:
patent: 3798031 (1974-03-01), Janssens et al.
patent: 3830647 (1974-08-01), Janssens et al.
patent: 3928686 (1975-12-01), Poot et al.
patent: 3979394 (1976-09-01), Janssens et al.
A. Schultz et al., J.C.S. Chem. Comm., 1976, p. 925.
A. Schultz et al., J.A.C.S., 100:7, Mar. 1978, 2150-2162.

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