Intermediates for the preparation of dideoxycarbocyclic nucleosi

Details Intermediates for the preparation of dideoxycarbocyclic nucleosi Intermediates for the preparation of dideoxycarbocyclic nucleosi

1991-06-05

1992-12-29

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544326, C07D23930

Patent

active

051752921

ABSTRACT:
A therapeutic method is provided, employing an antiviral compound of the general formula: ##STR1## wherein Z is H, OR' or N(R) .sub.2, wherein R' is H, (C.sub.1 -C.sub.4)alkyl, aryl, CHO, (C.sub.1 -C.sub.16)alkanoyl or O.dbd.P(OH) .sub.2, Y is CH or N, and X is selected from the group consisting of H, N(R) .sub.2, SR, OR' or halogen, wherein R is H, lower (C.sub.1 -C.sub.4)alkyl, aryl or mixtures thereof, and the pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 3775397 (1973-11-01), Etzold et al.
patent: 3817982 (1974-06-01), Verheyden et al.
patent: 3917837 (1975-11-01), Lin et al.
patent: 4076711 (1978-02-01), Ganguly et al.
patent: 4115438 (1978-09-01), Woessner
patent: 4138562 (1979-02-01), Vince
patent: 4223156 (1980-09-01), Vince
patent: 4268672 (1981-05-01), Vince
patent: 4362729 (1982-12-01), Vince
patent: 4383114 (1983-05-01), Vince
patent: 4543255 (1985-09-01), Shealy et al.
patent: 4636383 (1987-01-01), Nagabhushan et al.
patent: 4710492 (1987-12-01), Lin
patent: 4724232 (1988-02-01), Rideout et al.
patent: 4742064 (1988-05-01), Vince
patent: 4859677 (1989-08-01), Borchardt et al.
patent: 4880782 (1989-11-01), Eckstein et al.
patent: 4916122 (1990-04-01), Chu et al.
patent: 4916224 (1990-04-01), Vince et al.
patent: 4931559 (1990-06-01), Vince et al.
patent: 4950758 (1990-08-01), Vince et al.
patent: 4999428 (1991-03-01), Saksena et al.
patent: 5034394 (1991-07-01), Daluge
NIH Grant No. 1 R01 CA 23263-01A1 (Feb. 21, 1979).
NIH Grant No. 5 R01 CA 23263-02 (Dec. 10, 1979).
NIH Grant No. 5 R01 CA 23263-02 (Jun. 13, 1980).
NIH Grant No. 5 R01 CA 23263-03 (Dec. 31, 1980).
NIH Grant No. 2 R01 CA 23263-04A1 (Apr. 11, 1983).
NIH Grant No. 5 R01 CA 23263-05 (Dec. 15, 1983).
NIH Grant No. 5 R01 CA 23263-06 (Dec. 14, 1984).
NIH Grant No. 5 R01 CA 23263-08 (Jun. 19, 1987).
M. Baba et al., Biochem. Biophys. Res. Comm., 142, 128 (1987).
J. Balzarini et al., Molec. Pharmacol., 32, 162 (1987).
P. Herdewijn et al., J. Med. Chem., 30, 1270 (1987).
J. Balzarini et al., Biochem. Biophys. Res. Comm., 140, 735 (1986).
J. Balzarini et al., Biochem. Pharmacol., 37, 2847 (1988).
S. Broder, Ed., AIDS: Modern Concepts and Therapeutic Challenges, Marcel Dekker, Inc., N.Y. (1987) at page 320.
K. R. Brouwer et al., Drug Metabolism and Disposition, 18, 1078 (1990).
S. G. Carter et al., Antimicrobial Agents and Chemotherapy, 34, 1297 (1990).
C. K. Chu et al., Biochem. Pharmacol. 37, 3543 (1988).
J. K. Coward et al., J. Med. Chem., 16, 460 (1973).
M. A. Fischl et al., New Engl. J. Med., 317, 185 (1987).
Y. Hamamoto et al., Antimicrob. Agents Chemother., 31, 907 (1987).
P. Herdewijn et al., J. Med. Chem., 30, 2131 (1987).
P. Herdewijn et al., J. Med. Chem., 31, 2040 (1988).
J. P. Horwitz et al., J. Org. Chem., 32, 817 (1967).
Y. Ito et al., Tetrahedron Letters, 2521 (1979).
H. Lee and R. Vince, J. Pharm. Sci., 69, 1019 (1980).
T.-S. Lin et al., Biochem. Pharmacol., 36, 311 (1987).
T.-S. Lin et al., J. Med. Chem., 30, 440 (1987).
T.-S. Lin et al., J. Med. Chem., 31, 336 (1988).
T.-S. Lin et al., Biochem. Pharmacol., 36, 2713 (1987).
H. Mitsuya et al., Proc. Natl. Acad. Sci. USA, 83, 1911 (1986).
H. Mitsuya et al., Proc. Natl. Acad. Sci. USA 84, 2033 (1987).
V. Nair et al., J. Org. Chem., 52, 1344 (1987).
E. C. Reisinger et al., The Lancet, 335, 679 (1990).
E. G. Sandstrom et al., Drugs, 34, 372 (1987).
D. V. Santi et al., Biochemistry, 10, 4821

Affiliated with

Also associated with

Rating

Intermediates for the preparation of dideoxycarbocyclic nucleosi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intermediates for the preparation of dideoxycarbocyclic nucleosi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediates for the preparation of dideoxycarbocyclic nucleosi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1888472