Intermediates for the preparation of carbacephems

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D47104, C07D41304, C07B 4304

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active

056440510

ABSTRACT:
This invention is directed to carbacephems and methods for their preparation: ##STR1## In the foregoing formulae, R.sup.3 represents phenyl, C.sub.1 -C.sub.4 alkylphenyl, halophenyl, C.sub.1 -C.sub.4 alkoxyphenyl, naphthyl, thienyl, furyl, benzothienyl, or benzofuryl.

REFERENCES:
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patent: 5095107 (1992-03-01), Blanchard
Jackson et al., Synthesis of Carbacephem Antibiotics:Synthesis via Dieckmann Reaction Using Phenylesters to Direct the Regioselectivity of the Cyclization, 31 Tetrahedron Letters 6317 (1990).
Muller et al., Helvetica Chimica Acta, vol. 74:767-773 (1991).
Spitzer, J. Org. Chem. 39:2468 (1974).
Liotta, J. Org. Chem. 45:2887 (1980).
Piatak, J. Org. Chem. 34:116 (1969).
Ayers et al., J.C.S. Chem. Comm., 1972, p. 428.
Wolfe et al., Chem. Comm., 1970, pp. 1420-1421.
Caputo et al., The Oxidation of Cyclobutanols and Aromatic Rings with Ruthenium Tetroxide, 47 Tetrahedron Letters 4729-4731 (1967).
Klein et al., Umsetzung Adsorbierter Aromaten Mit Ozon, 48 Tetrahedron Letters 4249-4250 (1975).
Deno et al., Aromatic Ring Oxidation of Alkylbenzenes, 20 Tetrahedron Letters 1703-1704 (1977).

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