Intermediates for the preparation of beta-lactam antibiotics

Details Intermediates for the preparation of beta-lactam antibiotics Intermediates for the preparation of beta-lactam antibiotics

1990-07-20

1991-10-01

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540221, C07D50118

Patent

active

050535005

ABSTRACT:
Cephalosporin derivatives of the formulae ##STR1## wherein X is sulphur, oxygen, methylene or sulphinyl, R3 is hydrogen or methoxy, R54 is hydrogen or a carboxyl protecting group, R.sup.51 is a (1-4C)alkyl group, R.sup.4 is hydrogen, (1-4C)alkyl, halo(1-4C)alkyl, hydroxy(1-4C)alkyl, (1-4C)alkoxy(1-4C)alkyl, carboxy (1-4C)alkyl, amino (1-4C)alkyl, cyano(1-4C)alkyl, (1-4C)alkanoylamino(1-4C)alkyl, allyl, furfuryl, benzyl or pyridyl(1-4C)alkyl and R.sup.52 is an amino protecting group and salts thereof are useful as intermediates in the preparation of cephalosporin antibiotics.

REFERENCES:
patent: 3539562 (1970-11-01), Diassi et al.
patent: 3644347 (1972-02-01), Webber et al.
patent: 4278793 (1981-07-01), Durckheimer et al.
patent: 4347358 (1982-08-01), Bruynes
patent: 4386089 (1983-05-01), Konig et al.
patent: 4457929 (1984-07-01), Kamachi et al.
patent: 4614819 (1986-09-01), Nagai et al.
Chemical Abstracts vol. 107 236361x.

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