Intermediates for the preparation of 7-acylamino-3-oxyiminomethy

Details Intermediates for the preparation of 7-acylamino-3-oxyiminomethy Intermediates for the preparation of 7-acylamino-3-oxyiminomethy

1976-04-05

1977-10-11

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 544 22, 544 16, 544 29, C07D50118

Patent

active

040534693

ABSTRACT:
An antibacterial 7-protected amino-3-oxyiminomethyl-3-cephem-4-carboxylic acid is prepared by the reaction of a 7-protected amino-3-formyl-3-cephem-4-carboxylic acid or its reactive derivatives with a hydroxylamine compound or its reactive derivatives, the process being more suitable for large scale production when coupled with fermentative production of a 3-hydroxymethyl-3-cephem-4-carboxylic acid followed by its direct oxidation.

REFERENCES:
patent: 3674784 (1972-07-01), Webber
patent: 3840533 (1974-10-01), Dolfini et al.
patent: 3917587 (1975-11-01), Chauvette
patent: 3917588 (1975-11-01), Chauvette
patent: 3987039 (1976-10-01), Yoshioka et al.

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