Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2001-09-05
2003-05-27
Gerstl, Robert (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
06570021
ABSTRACT:
The present invention relates to novel products which may be used as intermediates for the preparation of 2-imidazolin-5-ones for fungicidal use. The invention also relates to the processes for the preparation of these novel products and to a process which is useful for obtaining these 2-imidazolin-5-ones from these novel intermediates.
2-Imidazolin-5-ones for fungicidal use are known, in particular from European patent publications EP 0551048, EP 0599749 and EP 0629616 and from International publication WO 93/24467.
One aim of the present invention is to propose novel intermediates which allow the preparation of these 2-imidazolin-5-ones.
Another aim of the present invention is to propose a novel route of access to fungicidal 2-imidazolin-5-ones which is of improved safety.
The subject of the invention is thus, firstly, 2-thiothiazolidin-5-ones of general formula (I):
in which:
R
1
is a C
1
-C
3
alkyl or phenyl radical,
R
2
is an aryl group chosen from phenyl or pyridyl, which is optionally substituted with 1 to 3 groups chosen from a halogen atom, a nitro or cyano group and a C
1
-C
3
alkyl or C
1
-C
3
alkoxy radical; with the exception of 4-ethyl4-phenyl-2-thiothiazolidin-5-one.
The subject of the invention is also the salified forms, as well as the stereoisomers of the compounds of formula (I). The subject of the invention is, in particular, the optical isomers resulting from the presence of an asymmetric carbon, and most particularly, when the radicals R
1
and R
2
are different, the optical isomers resulting from the presence of the asymmetric carbon bearing R
1
and R
2
. These optical isomers are optically pure compounds or compounds that are highly enriched in one enantiomer. In the following text, the expression optically active compound that is highly enriched in a given enantiomer is understood to refer to a compound containing at least 80%, preferably at least 90%, of this enantiomer. All these compounds are considered as being included in formula (I) defined above.
Among the compounds of formula (I), those are preferred for which:
R
1
represents a C
1
-C
3
alkyl radical,
R
2
represents a phenyl optionally substituted with a halogen atom, a cyano or nitro group or a methyl or methoxy radical.
Even more particularly, among the compounds of formula (I), those for which R
2
is a phenyl and R
1
is a methyl are preferred.
According to a very advantageous variant of the invention, the compound of formula (I) in which:
R
1
is a methyl and
R
2
is a phenyl, is an enantiomer relative to the asymmetric carbon bearing R
1
and R
2
.
In the present description, all the groups appearing in the chemical formulae which follow, and which have already been defined in the general formula (I), retain the same meaning unless specifically stated otherwise. The alkyl radicals mentioned in the present text may be linear or branched.
One mode of preparation of the compound of formula (I) is now described. This mode of preparation is indicated in the case of compounds which are racemic relative to the carbon bearing the radicals R
1
and R
2
. A person skilled in the art may, however, use these same reactions when he or she wishes to obtain a compound of formula (I) which is enantiomeric relative to the carbon bearing R
1
and R
2
. The reason for this is that the reactions indicated below are entirely stereoselective, in the sense that they do not result in any change in the absolute configuration of this same carbon.
The compound of formula (I) may be obtained by reacting a compound of formula (II) with carbon sulphide, in a solvent or a mixture of solvents, optionally in the presence of a base, at a temperature of between 0° C. and +50° C., according to the following scheme:
in which R
3
is an amino or hydroxyl group or a linear or branched alkoxy radical containing from 1 to 6, preferably from 1 to 3, carbon atoms or a benzyloxy radical optionally substituted with a halogen atom.
The base optionally used may be an inorganic base such as an alkali-metal or alkaline-earth metal hydroxide or carbonate or an organic base such as a primary, secondary or tertiary amine. It may be used in a base/compound II ratio (expressed as number of moles) of between 0.05 and 1.2, preferably between 0.1 and 1.
In this scheme, the compound of formula (III) may be isolated as an intermediate, in the case where a base is used, in the form of a salt.
Solvents which may be used are water, ethers, cyclic ethers, alkyl esters, dipolar solvents such as acetonitrile, alcohols of 1 to 4 carbon atoms, aromatic solvents, preferably toluene, dichloromethane or chloroform, and carbon sulphide. Mixtures of solvents which may be used are the mixture of one or more alcohols with one or more of the abovementioned solvents.
When R
3
is a hydroxyl group, it is preferred to use water as solvent.
When R
3
is other than a hydroxyl group, it is preferred to use an alcohol/water mixture as solvent.
In the case where the compound of formula (III) is isolated, it may be converted directly into compound (I) by heating to a temperature ranging from 25° C. to the reflux temperature of the solvent used. The conversion of intermediate compound (III) into compound (I) may also be carried out by treatment with a strong acid which is either an inorganic acid such as hydrochloric acid or sulphuric acid, or an organic acid such as trifluoroacetic acid.
It is preferred to carry out this process in the absence of base or at a temperature of between 20 and 40° C. In this case, the compound of formula (III) is not isolated.
Other modes of the procedure which allow compound (I) to be prepared starting from (II) are described by A. C. Davis and A. J. Levy in
J. Chem Soc.,
pp. 2419-25 (1951) or by K. Hofmann et al. in
J. Am. Chem. Soc.,
vol. 74, pp. 470-476 (1952).
The &agr;-amino ester of formula (II) in which R
3
is an alkoxy radical may be obtained by esterification of the corresponding &agr;-amino acids according to a procedure similar to that described by M. Brenner and W. Huber in
Helv Ch. Acta.
(1953), volume 36, pages 1109-1115.
The &agr;-amino amide of formula (II) in which R
3
is an amino group may be obtained from an amino ester by the action of ammonia as described by J. A. Garbarino in
Ann. Chimica Ital.
vol. 59, pp. 842-849 (1969).
The &agr;-amino acids are prepared by reactions and methods that are known per se.
When the compound of formula (II) is an amino ester enantiomer, it may be obtained in particular by:
diastereoselective amination of a prochiral compound followed by deprotection of the chiral couple as described by R. S. Atkinson et al,
Tetrahedron,
1992, 48, pp. 7713-30, or by
resolution of the corresponding racemic mixture with a chiral compound, as described by Y. Sugi and S. Mitsui,
Bull. Chem. Soc. Japan,
1969, 42, pp. 2984-89, or alternatively by
esterification of a chiral amino acid, as described by D. J. Cram et al.,
J. Am. Chem. Soc.,
1961, 83, pp. 2183-89.
When the compound of formula (II) is an amino amide enantiomer, it may be obtained either starting from a chiral amino ester or by resolution of the corresponding racemic mixture, as described by H. Dahn et al. in
Helv. Chim. Acta,
vol. 53, pp. 1370-1378 (1970).
The 2-thiothiazolidin-5-ones of formula (I) are useful for the preparation of fungicidal 2-imidazolin-5-ones of formula (IV):
in which:
M represents an oxygen or sulphur atom;
R
30
represents a linear or branched alkyl radical containing from 1 to 6 carbon atoms or a linear or branched haloalkyl radical containing from 1 to 6 carbon atoms;
R
4
represents a hydrogen atom or an acyl radical;
R
5
represents an aryl or heteroaryl radical chosen from: phenyl, naphthyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, thienyl, benzothienyl, furyl, benzofuryl, quinolyl, isoquinolyl or methylenedioxyphenyl, each of these radicals optionally being substituted with 1 to 7 groups, which may be identical or different, preferably from 1 to 3, chosen from the meanings of R
51
defined below;
R
51
represents:
a halogen atom or
an alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio
Buforn Albert
Gadras Alain
Burns Doane Swecker & Mathis L.L.P.
Gerstl Robert
Rhone-Poulenc Agro
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