Intermediates for the preparation of 1,3,dihydro-2H-imidazo[4,5-

Details Intermediates for the preparation of 1,3,dihydro-2H-imidazo[4,5- Intermediates for the preparation of 1,3,dihydro-2H-imidazo[4,5-

1995-04-18

1996-07-30

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544128, 546 14, 546159, 546 82, C07D40110, C07D41310, C07D21538, C07F 710

Patent

active

055413250

ABSTRACT:
The present invention relates to compounds of the formula ##STR1## wherein R represents hydrogen; C.sub.1-6 alkyl; C.sub.3-6 cycloalkyl; phenyl optionally substituted with from 1 to 3 substituents each independently selected from halo, hydroxy, C.sub.1-6 alkyloxy, C.sub.5-6 cycloalkyloxy, C.sub.1-6 alkyl or trifluoromethyl; pyridinyl; or thienyl optionally substituted with halo or C.sub.1-6 alkyl; and
.dbd.C.dbd.X is a radical of the formula:

REFERENCES:
patent: 4701459 (1987-10-01), Meanwell et al.
patent: 4943573 (1990-07-01), Meanwell
patent: 5043327 (1991-08-01), Freyne et al.
patent: 5342842 (1994-08-01), Cheng
Meanwell et al, J. Med. Chem. 35, pp. 2672-2687 (Jul. 10, 1992).
Beavo et al, TIPS 11 pp. 150-155 (1990).
Nicholson et al, TIPS 121 pp. 19-27 (1991).

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