Intermediates for the preparation of 1',1'-disubstituted and 1'-

Details Intermediates for the preparation of 1',1'-disubstituted and 1'- Intermediates for the preparation of 1',1'-disubstituted and 1'-

1995-08-29

1997-06-24

Datlow, Philip I.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

5142292, C07D49808, C07D49818, C07F 707

Patent

active

056418825

ABSTRACT:
The invention relates to a novel process for stereocontrolled preparation of 1',1'-disubstituted and 1'-spiro-nucleosides of the formula I ##STR1## in which the substituents A, R.sub.8 and R.sub.9 are as defined in claim 1, and to novel intermediates and their use in this process and to processes for the preparation of the novel intermediates. The process is illustrated by the example of biologically active (+)-hydantocidin.

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