Intermediates for synthesis of tetramisole, levamisole and their

Details Intermediates for synthesis of tetramisole, levamisole and their Intermediates for synthesis of tetramisole, levamisole and their

1978-03-08

1979-02-13

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23370, C07D23390

Patent

active

041397070

ABSTRACT:
A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, dl-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.

REFERENCES:
patent: 3726894 (1973-04-01), Spicer
Rodionov et al., Chem. Abst. 1949, vol. 43, col. 3821.
Kametani Chem. Abst. 1952, vol. 46, cols. 4547-4548.
Raeymaekers et al., J. Med. Chem. 1966, vol. 9, pp. 545-551.

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