Intermediates for synthesis of cephalosporins and process...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C540S225000, C540S227000, C540S228000, C558S028000

Reexamination Certificate

active

07452990

ABSTRACT:
A novel 4-halo-2-oxyimino-3-oxo butyric acid-N,N-dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibioticswhereinX is chlorine or bromine; R is hydrogen, C1-4alkyl group, an easily removable hydroxyl protective group, —CH2COOR5, or —C(CH3)2COOR5, wherein R5is hydrogen or an easily hydrolysable ester group. The compound of formula (I) is prepared by reacting 4-halo-2-oxyimino-3-oxobutyric acid of formula (IV1),wherein X, R and R5are as defined above, with N,N-dimethylformiminium chloride chlorosulphate of formula (VII)in an organic solvent at a temperature ranging from −30° C. to −15° C. The cephalosporins that may be prepared from the intermediate include cefdinir, cefditoren pivoxil, cefepime, cefetamet pivoxil, cefixime, cefmenoxime, cefodizime, cefoselis, cefotaxime, cefpirome, cefpodoxime proxetil, cefquinome, ceftazidime, cefteram pivoxil, ceftiofur, ceftizoxime, ceftriaxone and cefuzonam.

REFERENCES:
patent: 5037988 (1991-08-01), Diago Meseguer et al.
patent: 5739346 (1998-04-01), Datta et al.
patent: 5831085 (1998-11-01), Datta et al.
patent: 6458949 (2002-10-01), Handa et al.
patent: 0 791 597 (1997-08-01), None

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Intermediates for synthesis of cephalosporins and process... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intermediates for synthesis of cephalosporins and process..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediates for synthesis of cephalosporins and process... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4033262

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.