Intermediates for substituted biphenylmethylmidazopyridine angio

Details Intermediates for substituted biphenylmethylmidazopyridine angio Intermediates for substituted biphenylmethylmidazopyridine angio

1995-06-06

1996-09-24

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5462714, 5462821, 546308, 5462844, C07D41310, C07D21375

Patent

active

055592368

ABSTRACT:
The present invention provides an industrially advantageous process for preparing a 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin II receptor useful as an antihypertensive drug, a biphenyl derivative which is a precursor of the substituent of the pyridine derivative, a process for the preparation thereof, and an intermediate useful for the preparation of the biphenyl derivative: ##STR1## The 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo-[4,5-b]pyridine derivative can be prepared in a high yield according to the present invention from a 2-amino-5-halogeno-3-nitropyridine derivative through amidation, N-alkylation and reductive cyclization. The halogen atom introduced at the 5-position as a protective group against nitration can be eliminated simultaneously in the step which is conducted thereafter. Thus, this process is industrially advantageous. Further, the biphenyl derivative of the present invention is excellent in reactivity and purity of the product, thus being an intermediate suitable for the industrial production.

REFERENCES:
patent: 5102880 (1992-04-01), Chakravarty et al.
patent: 5157026 (1992-10-01), Chakravarty et al.
patent: 5250548 (1993-10-01), Winn et al.
patent: 5332744 (1994-07-01), Chakravarty et al.
Organic Syntheses, Collective vol. 2, rev. of Annual Vol. X-XIX, pp. 134-137 (1936).
A. I. Meyers, et al., J. Org. Chem., vol. 39, No. 18, 1974, pp. 2778-2783.
Nicholas A. Cortese, et al., J. Org. Chem., vol. 42, No. 22, 1977, pp. 3491-3495.
Mervyn Israel, et al., Pyridopyrazines and Imidazopyridines, vol. 24, Oct. 1959, pp. 1455-1460.
Harold Graboyes, et al., Syntheses of Imidazopyridines and Pyridotriazoles, vol. 79, Dec. 20, 1957, pp. 6421-6427.
A. I. Meyers, et al., J. Org. Chem., vol. 43, No. 7, 1978, pp. 1372-1379.
Atwal, K. et al., J. Med. Chem. 1992, 35, (pp. 4751-4763).

Affiliated with

Also associated with

Rating

Intermediates for substituted biphenylmethylmidazopyridine angio does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intermediates for substituted biphenylmethylmidazopyridine angio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediates for substituted biphenylmethylmidazopyridine angio will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1929501