Intermediates for steroid total synthesis process utilizing asym

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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2603436, 2603458R, 2603459S, 2603478, 2603974, 2604105, 260465D, 260465F, 2605705C, 2605705CA, 560 8, 560107, 560221, 568327, C07C 4984, C07C 6916

Patent

active

042018692

ABSTRACT:
A multi-step, stereospecific total synthesis of steroids is disclosed. The starting materials for this process are the relatively inexpensive and readily available m-alkoxy acetophenones. The process is suitable for the preparation of racemic or optically active, medicinally valuable steroids, particularly A-ring aromatic steroids. This process features an early optical resolution and a unique asymmetric induction which insures the correct stereochemistry of the final steroidal product.

REFERENCES:
patent: 3932519 (1976-01-01), Cohen et al.
patent: 3975440 (1976-08-01), Hajos et al.
patent: 4011211 (1977-03-01), Cohen et al.

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