Intermediates for steroid total synthesis process utilizing asym

Details Intermediates for steroid total synthesis process utilizing asym Intermediates for steroid total synthesis process utilizing asym

1975-09-24

1978-05-30

Garner, Vivian

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

2603436, 2603458R, 2603459S, 2603478, 2603974, 2604105, 260465D, 260465F, 2605705C, 2605705CA, 260590FA, 260590FB, 260590R, 260613D, 260613R, 560 8, 560107, C07C 4984, C07C 6916

Patent

active

040924831

ABSTRACT:
A multi-step, stereospecific total synthesis of steroids is disclosed. The starting materials for this process are the relatively inexpensive and readily available m-alkoxy acetophenones. The process is suitable for the preparation of racemic or optically active, medicinally valuable steroids, particularly A-ring aromatic steroids. This process features an early optical resolution and a unique asymmetric induction which insures the correct stereochemistry of the final steroidal product.

REFERENCES:
patent: 2726267 (1955-12-01), Johnson et al.
patent: 3317566 (1967-05-01), Whitehurst et al.
patent: 3417105 (1968-12-01), Hughes et al.
patent: 3458579 (1969-07-01), Hughes et al.

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