Intermediates for pyrrolidylthiocarbapenem derivative

Details Intermediates for pyrrolidylthiocarbapenem derivative Intermediates for pyrrolidylthiocarbapenem derivative

1995-12-19

1997-12-30

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548544, 548556, C07D20712

Patent

active

057032432

ABSTRACT:
A pyrrolidylthiocarbapenem derivative represented by Formula I is provided: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; R.sup.2, R.sup.3 and R.sup.4 are hydrogen, lower alkyl which can be substituted or an amino protecting group independently, or R.sup.2 and R.sup.3 together with a nitrogen atom to which R.sup.2 and R.sup.3 are bonded form a saturated or unsaturated cyclic group, or R.sup.2 and R.sup.4, or R.sup.3 and R.sup.4 together with two nitrogen atoms and one sulfur atom in the sufamide group form a saturated or unsaturated cyclic group; each cyclic group can further include at least one atom selected from the group consisting of oxygen, sulfur and nitrogen, and each cyclic group can be substituted; X.sup.1 is hydrogen or a hydroxy protecting group; X.sup.2 is hydrogen, a carboxy protecting group, an ammonio group, an alkali metal or an alkaline-earth metal; and Y.sup.2 is hydrogen or an amino protecting group.

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Official Action dated Jul. 11, 1996 issued by Norwegian Patent Office for No. Application 923256.
Thornber; "Isosterism & Molecular Modification in Drug Design," Imperial Chemical Indus. , U.K., pp. 563-580.

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