Intermediates for producing quinolone-3-carboxylic acids

Details Intermediates for producing quinolone-3-carboxylic acids Intermediates for producing quinolone-3-carboxylic acids

1989-08-21

1991-02-19

Gray, Bruce

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 9, 558 44, 558 58, C07C22900

Patent

active

049945998

ABSTRACT:
A process for producing a 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid by reacting an acctophenone with a dialkoxycarbonate to obtain the corresponding .beta.-ketoester, treating the .beta.-ketoester with a trialkylorthoformate in the presence of an acid anhydride followed by treatment with a substituted or unsubstituted amine to obtain the corresponding enaminoketoester, and then reacting the enaminoketoester with a strong base to obtain the corresponding quinoline-3-carboxylic acid ester. The acid ester may then be hydrolyzed, if desired, to obtain the quinoline-3-carboxylic acid. Also disclosed herein are compounds useful as intermediates useful in the production of quinoline-3-carboxylic acid.

REFERENCES:
patent: 4284629 (1981-08-01), Grohe et al.

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