Intermediates for producing enyne derivatives

Details Intermediates for producing enyne derivatives Intermediates for producing enyne derivatives

1993-11-18

1994-10-25

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 51, 549 55, 549 59, 549 74, 549 75, 564384, 564387, 564389, 564509, C07D21102, C07D33358

Patent

active

053590910

ABSTRACT:
A compound of the formula: ##STR1## wherein R.sup.11 is hydrogen, lower alkyl, haloloweralkyl, lower alkenyl, lower alkynyl or cycloalkyl; R.sup.21 is a group of the formula: ##STR2## wherein each of R.sup.3, R.sup.31, and R.sup.32 which may be the same or different, is hydrogen or lower alkyl, each of R.sup.4, R.sup.5, R.sup.41 and R.sup.51, which may be the same or different, is hydrogen, halogen, hydroxyl, lower alkyl or lower alkoxy, R.sup.42 is hydroxyl, halogen, R.sup.8 --O--, or R.sup.6 --X--Y-- wherein R.sup.6 is phenyl or thienyl which may have one or two substituents each of X and Y, which may be the same or different, is oxygen, sulfur, carbonyl, --CHR.sup.8 -- or --NR.sup.b, or X and Y together form a vinylene group or an ethynylene group, provided that when either one of X and Y is oxygen, sulfur or --NR.sup.b, the other is carbonyl or --CHR.sup.a, and R.sup.7 is lower alkyl or cycloalkyl which may be substituted by hydroxy or lower alkoxy, phenyl or tri-lower alkylsilyl; and W is chlorine or bromine.

REFERENCES:
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Madelmont et al, Chemical Abstracts, vol. 86(1977) 43070r.
Behner et al, Chemical Abstracts, vol. 95(1981) 25050r.
Tilles, JACS, vol. 81, No. 3 (1959) pp. 714-727.
Rudisill et al, Tetrahedron Letters, vol. 29, No. 13 (1988) pp. 1509-1512.
Bottini et al, Chemical Abstracts, vol. 58(1963) 5493a.
Geisler et al, Chemical Abstracts, vol. 63(1965) 12999f.
Garst et al, J. Org. Chem., vol. 46(1981) pp. 4433-4438.

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