Intermediates for preparing substituted pyrimidinones

Details Intermediates for preparing substituted pyrimidinones Intermediates for preparing substituted pyrimidinones

1982-04-07

1984-10-16

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544123, 544295, 544296, 544319, 544320, 544321, 544333, 424251, C07D40106

Patent

active

044776632

ABSTRACT:
A series of chemical reactions starting from the condensation of uracil with an acid stable heterocyclic aldehyde in an acid medium produces biologically active end products which are 2-heterocyclylmethylthioethylamino-5-heterocyclylmethyl-4-pyrimidinones. The new reactions and intermediates of this invention are particularly useful for preparing 2[2-(5-dimethylaminomethyl-2-furylmethylthio)-ethylamino]-5-(6-methyl-3-py ridylmethyl)-4-pyrimidinone and its salts. This compound is a potent H.sub.2 -antagonist with a long duration of activity.

REFERENCES:
patent: 4145546 (1979-03-01), Brown et al.
patent: 4227000 (1980-10-01), Brown
patent: 4305945 (1981-12-01), Ganellin et al.
patent: 4352933 (1982-10-01), Lam et al.

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