Intermediates for preparing pirbuterol and analogs

Details Intermediates for preparing pirbuterol and analogs Intermediates for preparing pirbuterol and analogs

1984-08-16

1986-12-30

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546300, 546301, C07D21365, C07D491056

Patent

active

046329927

ABSTRACT:
Processes and intermediates useful in the preparation of bronchodilator compounds of the formula ##STR1## wherein R is hydrogen, methyl or hydroxymethyl are described. Those compounds wherein R is H or CH.sub.3 have been found to have further utility as intermediates for pirbuterol (wherein R is hydroxymethyl).

REFERENCES:
patent: 3700681 (1972-10-01), Barth
patent: 3786160 (1974-01-01), Barth
patent: 3873557 (1975-03-01), Abblard et al.
patent: 3948919 (1976-05-01), Nakanishi
patent: 3952101 (1976-04-01), Jen et al.
patent: 4011231 (1977-03-01), Carroll et al.
patent: 4031108 (1977-06-01), Nakanishi
Benderly et al., Can. J. Chem. 56, pp. 2673-2676 (1978).

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