Intermediates for preparing cephalosporins and methods of produc

Details Intermediates for preparing cephalosporins and methods of produc Intermediates for preparing cephalosporins and methods of produc

1972-11-29

1976-06-22

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07B50102

Patent

active

039650987

ABSTRACT:
.DELTA..sup.3 -CEPHALOSPORINS ARE PREPARED BY REACTING NOVEL DIORGANODIHALOSILANE OR MONORGANODIHALOSILANE DERIVATIVES OF 7-AMINOCEPHALOSPORANIC ACID ("7ACA") and 7-amino-desacetoxycephalosporanic acid ("7ADCA") with known acylating agents followed by hydrolysis or alcoholysis to produce .DELTA..sup.3 -cephalosporins with useful antibiotic activity. The dialkyldihalosilane derivatives are prepared by adding a base such as triethylamine slowly to a mixture of 7ACA or 7ADCA and a dialkyldihalosilane.

REFERENCES:
patent: 3694437 (1972-09-01), Jackson
patent: 3708476 (1973-01-01), Woodward
patent: 3741959 (1973-06-01), Looker et al.

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