Intermediates for preparing cephalosporins

Details Intermediates for preparing cephalosporins Intermediates for preparing cephalosporins

1976-03-22

1977-09-27

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 544 23, 544 30, C07D50118

Patent

active

040511316

ABSTRACT:
.DELTA..sup.3 -Cephalosporins are prepared by reacting novel diorganodihalosilane or monorganodihalosilane derivatives of 7-aminocephalosporanic acid ("7ACA") and 7-amino-desacetoxycephalosporanic acid ("7ADCA") with known acylating agents followed by hydrolysis or alcoholysis to produce .DELTA..sup.3 -cephalosporins with useful antibiotic activity. The dialkyldihalosilane derivatives are prepared by adding a base such as triethylamine slowly to a mixture of 7ACA or 7ADCA and a dialkyldihalosilane.

REFERENCES:
patent: 3694437 (1972-09-01), Jackson
patent: 3741959 (1973-06-01), Looker et al.

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