Intermediates for preparing anti-inflammatory phenyl-lower-alkyl

Details Intermediates for preparing anti-inflammatory phenyl-lower-alkyl Intermediates for preparing anti-inflammatory phenyl-lower-alkyl

1978-05-03

1980-08-05

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544158, 544159, 544162, 544174, 544175, 544170, 544 59, 544392, 544394, 544399, 544410, 544402, 544386, 544358, 544162, 546 19, 546245, 260239B, 2603265S, 2603265C, 26032684, 26032685, 260570R, 2605706, 2605707, 544244, 544267, 544274, 544250, 544246, 2603459R, C07D21106

Patent

active

042163269

ABSTRACT:
N-{3- and 4-[R.sub.1 -(phenyl)-C(.dbd.X)]-phenyl-lower-alkyl}amines, useful as anti-inflammatory agents, are prepared either by reduction of 3- or 4-[R.sub.1 -(phenyl)-CO]-phenyl-lower-alkanoylamines, which are also useful as anti-inflammatory agents; by benzoylating a phenyl-lower-alkylamine; by reaction of a 3- or 4-lithiophenyl-lower-alkylamine with a R.sub.1 -(phenyl)-carboxaldehyde, a R.sub.1 -(phenyl)-lower-alkyl ketone or a R.sub.1 -(phenyl)-carbonitrile or by transformations involving manipulations of a carbonyl or carbinol group.

REFERENCES:
patent: 3770748 (1973-11-01), Borck et al.
patent: 3772311 (1973-11-01), Arya
patent: 3773772 (1973-11-01), Arya
patent: 3773944 (1973-11-01), Lippmann

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