Intermediates for preparing 2-(substituted-dibenzofuranyl and di

Details Intermediates for preparing 2-(substituted-dibenzofuranyl and di Intermediates for preparing 2-(substituted-dibenzofuranyl and di

1990-10-15

1992-09-29

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48704, C07F 708, A61K 3140

Patent

active

051515121

ABSTRACT:
Carbapenem intermediates having the formula: ##STR1## where Z is; ##STR2## M is a removable protecting group for carboxy and P' is a removable protecting group for hydroxy are useful intermediates for preparing antibacterial agents, especially with respect to activity against methicillin resistant Staphylococcus aureus (MRSA).

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patent: 5025006 (1990-06-01), Alzmann
patent: 5025008 (1990-05-01), DiNinno et al.
L. D. Cama et al., Total Synthesis of Thienamycin Analogs-III, Tetrahedron 39, 2531 (1983).
R. N. Guthikonda, et al., Structure Activity Relationships in the 2-Arylcarbapenem Series, J. Med. Chem., 30, 871 (1987).

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