Intermediates for preparing 2-(substituted-dibenzo-furanyl and d

Details Intermediates for preparing 2-(substituted-dibenzo-furanyl and d Intermediates for preparing 2-(substituted-dibenzo-furanyl and d

1990-10-11

1992-07-21

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48704, C07F 710

Patent

active

051324202

ABSTRACT:
Carbapenem intermediates having the formula: ##STR1## where Z is ##STR2## M is a removable protecting group for carboxy and P' is a removable protecting group for hydroxy, are useful intermediates for preparing antibacterial agents, especially with respect to activity against methicillin resistant Staphylococcus aureus (MRSA).

REFERENCES:
patent: 4260627 (1981-04-01), Christensen et al.
patent: 4465632 (1984-08-01), Christensen et al.
patent: 4543257 (1985-09-01), Cama et al.
patent: 4775669 (1988-10-01), Cama et al.
L. D. Cama et al., Total Synthesis of Thienamycin Analogs-III, Tetrahedron, 39, 2531 (1983).
R. N. Guthikonda, et al., Structure Activity Relationships in the 2-Arylcarbapenem Series, J. Med. Chem., 30, 871 (1987).

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