Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Patent
1988-05-09
1989-03-07
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
530332, C07K 706
Patent
active
048107786
ABSTRACT:
New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by the Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
REFERENCES:
patent: 4760052 (1988-07-01), Callahan et al.
Callahan James F.
Huffman William F.
Newlander Kenneth A.
Yim Nelson C. F.
Lourie Alan D.
Phillips Delbert R.
SmithKline Beckman Corporation
Suter Stuart R.
Williams Janice E.
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