Intermediates for preparing 1,2-dihydropyrido[3,4-b]-pyrazines

Details Intermediates for preparing 1,2-dihydropyrido[3,4-b]-pyrazines Intermediates for preparing 1,2-dihydropyrido[3,4-b]-pyrazines

1986-02-03

1987-02-24

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544350, C07D21375, C07D21361

Patent

active

046458409

ABSTRACT:
1,2-Dihydropyrido[3,4-b]pyrazines are provided which possess anticancer activity. The compounds have the structure: ##STR1## wherein Y is CH.sub.2 or N(CH.sub.3); R.sub.1 is a lower alkyl group; e.g., an alkyl group containing up to six carbon atoms such as methyl, ethyl, propyl, butyl, etc.; R.sub.2 is a member selected from the group consisting of hydrogen, CH.sub.3 O or Cl; and R.sub.3 and R.sub.4 are either both hydrogen or one is hydrogen and the other is a lower alkyl group.

REFERENCES:
patent: 3838154 (1974-09-01), Gerber
patent: 3995035 (1976-11-01), Folz et al.
patent: 4118368 (1978-10-01), Soma et al.
patent: 4450160 (1984-05-01), Temple et al.
patent: 4511721 (1985-04-01), Temple et al.
patent: 4600716 (1986-07-01), Temple et al.

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