Intermediates for preparation of (threo)-1-aryl-2-acylamido-3-fl

Details Intermediates for preparation of (threo)-1-aryl-2-acylamido-3-fl Intermediates for preparation of (threo)-1-aryl-2-acylamido-3-fl

1986-01-27

1987-06-30

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549554, 549563, C07D30308, C07D30322, C07D30334, C07D30336

Patent

active

046772146

ABSTRACT:
A novel sequence of highly selective chemical reactions for conversion of 3-Aryl-2-propyn-1-ols into cis-1-Aryl-3-fluoro-1-propene and into D,L-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanols is disclosed. Preparation of D-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanol antibacterial agents including the D-(threo)-3-fluoro-3-deoxy derivatives of chloramphenicol and thiamphenicol is also disclosed.

REFERENCES:
R. Krebs, CA 78:71663q and 77:61532m.
Jean Bensoam et al, Tetrahedron Letters, No. 4 (1979), pp. 353-356.

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