Intermediates for polycyclic quinonoid antibiotics

Details Intermediates for polycyclic quinonoid antibiotics Intermediates for polycyclic quinonoid antibiotics

1978-01-10

1979-04-03

Shaver, Paul F.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260376, 260383, 424331, 424340, C07C 8710

Patent

active

041477065

ABSTRACT:
There is provided a novel method of synthesizing certain tetracyclic quinones. In particular, there is provided a novel route to the synthesis of (+)-7-deoxydaunomycinone and analogs thereof, which includes the provision of novel tri- and tetracyclic quinone intermediates. The -7-deoxydaunomycinone derived from naturally occurring daunomycin is a known compound, which is itself an intermediate in the preparation of the clinically accepted anti-tumor antibiotics daunomycine and its derivative adriamycin.

REFERENCES:
patent: 3686163 (1972-08-01), Arcamone et al.
patent: 3803124 (1974-04-01), Arcamone et al.
patent: 3963760 (1976-06-01), Bernardi et al.
patent: 3987028 (1976-10-01), Lunel et al.
patent: 4070382 (1978-01-01), Kende et al.
patent: 4077988 (1978-03-01), Arcamone et al.

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