Intermediates for mefloquin

Details Intermediates for mefloquin Intermediates for mefloquin

1983-08-22

1985-10-01

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546176, C07D40514, C07D40506

Patent

active

045447489

ABSTRACT:
A process for the preparation of mefloquin and its physiologically compatible acid addition salts by reacting 6-phthalimido-1-hexene with a 4-halo-2,8-bis-(trifluoromethyl)-quinoline in the presence of a base, epoxidizing the resulting N-[6-<2,8-bis-(trifluoromethyl)-4-quinolyl>-5-hexenyl]-phthalimide to give N-[4-{3-<2,8-bis-(trifluoromethyl)-4-quinolyl>-2-oxiranyl}-butyl]-phthalim ide, treating the latter with hydrazine hydrate and, where applicable, converting the product into an acid addition salt as well as intermediates obtained in this process.

Affiliated with

Also associated with

Rating

Intermediates for mefloquin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Intermediates for mefloquin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Intermediates for mefloquin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1443491